Biochemical, cytological, and histological alterations in rat lung following acute beryllium aerosol exposure
Identifieur interne : 00EC10 ( Main/Exploration ); précédent : 00EC09; suivant : 00EC11Biochemical, cytological, and histological alterations in rat lung following acute beryllium aerosol exposure
Auteurs : Beth A. Hart [États-Unis] ; Allen G. Harmsen [États-Unis] ; Robert B. Low [États-Unis] ; Robert Emerson [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1984.
English descriptors
- Teeft :
- Academic press, Acid phosphatase, Acute beryllium aerosol exposure, Adherent cells, Adherent macrophages, Alkaline phosphatase, Alveolar cells, Alveolar macrophage, Alveolar macrophages, Beryllium, Beryllium aerosol exposure, Beryllium exposure, Cell hyperplasia, Control animals, Control values, Cytological, Cytological response, Days oxalic acid control beryllium, Days post beryllium exposure, Days postexposure, Disaturated phosphatidylcholine, Early indicators, Early lung damage, Enzymatic analyses, Experimental animals, Exposure chamber, Free alveolar cell population, Free alveolar cells, Granular pneumocytes, Histological alterations, Inflammatory reaction, Lactic dehydrogenase, Lavage, Lavage enzymes, Lavage fluid, Lavage fluid concentrations, Lavage fluids, Lavage protein, Lavageable, Lavageable compartment, Lipid, Lipid inclusions, Lipid levels, Lung cancer, Lung parenchyma, Lung tissue, Lysozyme, Macrophage, Macrophage number, Nonlavageable compartment, Nonlavageable compartments, Nonpolar lipids, Nonspecific phagocytosis, Osmium tetroxide, Other organs, Oxalate, Oxalate control animals, Oxalic, Oxalic acid control, Oxalic acid control animals, Oxalic acid control beryllium, Phagocytic, Phagocytic activity, Phagocytic function, Phosphatase, Phosphate buffer, Polar lipid, Polar lipid fraction, Polymorphonuclear leukocytes, Postexposure, Pulmonary response, Pulmonary toxicology, Respirable particles, Serum transudation, Sialic, Sialic acid, Standard deviation, Supranormal phagocytic activity, Technical information center, Time point, Total number, Transmission electron microscopy, Ultrasonic radiation, Unexposed control animals, Yeast, Yeast cell, Yeast phagocytosis.
Abstract
Abstract: Fischer 344 rats were exposed for 1 hr to an aerosol of BeO generated at a temperature of 560°C. An initial lung burden of 500 ± 4.1 ng Be was achieved. Animals were killed at 2.5 hr, and 2, 12, and 21 days postexposure. Bronchopulmonary lavage fluids were analyzed biochemically for enzymes, protein, lipids, and sialic acid, and cytologically to determine the composition of the free alveolar cell population. Nonspecific phagocytosis of yeast was measured in adherent macrophages. There were increases in all the biochemical parameters by 2 days postexposure, which peaked by Day 5 and then began to return to control levels. The cytological response on Days 2 and 5 was characterized by polymorphonuclear leucocyte infiltration and a depression in macrophage number and phagocytic activity. By Day 12, increased numbers of newly recruited macrophages with supranormal phagocytic activity populated the lung. During the same period, there was a reduction in lavage protein and lipid levels, perhaps due to a restoration of normal clearance mechanisms. Tissue morphological changes correlated well with the cytological and biochemical alterations.
Url:
DOI: 10.1016/0041-008X(84)90182-0
Affiliations:
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An initial lung burden of 500 ± 4.1 ng Be was achieved. Animals were killed at 2.5 hr, and 2, 12, and 21 days postexposure. Bronchopulmonary lavage fluids were analyzed biochemically for enzymes, protein, lipids, and sialic acid, and cytologically to determine the composition of the free alveolar cell population. Nonspecific phagocytosis of yeast was measured in adherent macrophages. There were increases in all the biochemical parameters by 2 days postexposure, which peaked by Day 5 and then began to return to control levels. The cytological response on Days 2 and 5 was characterized by polymorphonuclear leucocyte infiltration and a depression in macrophage number and phagocytic activity. By Day 12, increased numbers of newly recruited macrophages with supranormal phagocytic activity populated the lung. During the same period, there was a reduction in lavage protein and lipid levels, perhaps due to a restoration of normal clearance mechanisms. Tissue morphological changes correlated well with the cytological and biochemical alterations.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Vermont</li></region></list><tree><country name="États-Unis"><region name="Vermont"><name sortKey="Hart, Beth A" sort="Hart, Beth A" uniqKey="Hart B" first="Beth A." last="Hart">Beth A. Hart</name></region><name sortKey="Emerson, Robert" sort="Emerson, Robert" uniqKey="Emerson R" first="Robert" last="Emerson">Robert Emerson</name><name sortKey="Harmsen, Allen G" sort="Harmsen, Allen G" uniqKey="Harmsen A" first="Allen G." last="Harmsen">Allen G. Harmsen</name><name sortKey="Low, Robert B" sort="Low, Robert B" uniqKey="Low R" first="Robert B." last="Low">Robert B. Low</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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